https://safirsoft.com Pig hearts were first transplanted into humans
The transplant is a 'compassionate use' and is not part of a clinical trial.

The University of Maryland School of Medicine announced Monday that its staff has performed the first human heart transplant. The patient who received it had end-stage heart disease and was too sick to qualify for the standard transplant list. Three days after the operation, the patient was still alive

The idea of ​​using inhuman organs as a replacement for damaged human organs - called external grafts - has a long history, inspired by the fact that there are more people on the organ waiting list than donors. And in recent years, our ability to do targeted genetic modification has prompted people to genetically modify pigs to make them better donors. But the recent surgery was not part of a clinical trial, so it should not be taken as a sign that the procedure is ready for comprehensive testing for safety and efficacy.

Instead, the surgery was approved by the organization. The Food and Drug Administration has access to the "compassionate use" access program. This allows people with life-threatening illnesses to receive research therapies that have not yet undergone rigorous clinical trials.

The heart used for the transplant is made from a genetically modified line. It has been specifically designed to reduce it. There are a number of fonts engineered with this in mind that the human immune system might reject (some competing ideas show what needs correcting). The line was created by a company called Revivicor (now part of United Therapeutics), but the company doesn't provide any details about the exact changes on its website. Revivicor's research at ClinicalTrials.gov returns only one stroke containing a completely different pig streak. A press release from the University of Maryland stated that three genes were deleted from pigs to reduce their immune profile and prevent rejection, and a fourth gene to prevent "overgrowth" of pig cells. In addition, six human genes have been introduced into pigs to increase the resistance of the human immune system to foreign cells. While it is easy to guess what these genes are, the potential list of targets is much larger than what has actually been modified.

Because of the amount of effort it took to produce the fonts that were made kan. It's clearly a matter of time before these types of links are created. But the lack of details about the commercially developed heart donor means that it is difficult to judge the first attempt on a scientific level. The fact that the transplant was performed without a clear plan to assess the safety of the transplant raises the question of the usefulness of the first attempt.

However, from the human point of view, the person involved in the transplant. The hospital has now had a heart for months due to poor heart function. And maybe their ability to stay active can tell us something.



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