In the third phase of the trial, the drug cut hospitalization and mortality by about half. An oral antiviral drug appears to reduce the risk of COVID-19 hospitalization and death by about 50% in people who have recently been diagnosed with infection and are at high risk of contracting the disease. p>
People who had recently tested positive for SARS-CoV-2 infection participated in this trial. Symptoms of COVID-19 are mild to moderate in only the last five days of testing. Enumerators must also have at least one risk factor for poor outcomes, such as obesity, diabetes, heart disease, or age over 60. While some participants received placebo and standard care, others took the oral dose every 12 hours for five days.
After 29 days of follow-up, 53 of the 377 participants who received the placebo were hospitalized with COVID-19, eight of whom died. Of those who received the drug, only 28 of the 385 were hospitalized and none died. In other words, 7.3% of treated patients were hospitalized or died while 14.1% were in the placebo group. Merck also confirmed that the test is universal and appears to be equally effective against different types of SARS-CoV-2, including delta, gamma and mu. The drug manufacturer noted that it had viral genetic data to identify the types of 40 percent of participants. The safety data was equally promising, with participants reporting similar numbers of drug-related side effects among the placebo group. Drug group (11% and 12%, respectively): About 3.4% of the placebo group left the study due to side effects, while only 1.3% in the drug group.Advertising
The drug at the heart of this seemingly stunning result is called Mulnopiravir — a name inspired by Molnier, the Hammer of Thor. The idea is that this drug kills SARS-CoV-2 like a powerful blow from the god of lightning. Dean Lee, Merck's head of research and development, told Stat News that the new data proves the drug's legendary power. "Our prediction from our lab studies, and now with this data, is that mulnopiravir has been properly named [something]...it's a hammer against SARS-CoV-2, regardless of its type." Molnopiravir is a small molecule that acts on virus-dependent RNA polymerase, an enzyme needed to make a copy of RNA viruses such as SARS-CoV-2. The drug had been in use for years before SARS-CoV-2 appeared, and by March 2020, it was about to enter clinical trials for use against influenza. At the time, Ridgeback teamed up with nonprofit drug developers at Emory University to counter it against SARS-CoV-2. A few months later, in May, Ridgeback and Merck announced their collaboration to develop the drug, called EIDD-2801, to treat COVID-19. As a building block for molnopyravir RNA in the body, it is converted to the prankster ribonucleoside, which inadvertently assembles polymerase into the viral RNA strands instead of cytidine. This is basically fatal. Researchers call this effect the "viral error catastrophe," in which the rate of mutations or genetic errors exceeds the threshold corresponding to the residual virus. , very. For this reason, pregnant women were carefully excluded from the experiment. To date, however, all clinical and animal trials have suggested good safety results.
In early animal studies with other coronaviruses, SARS-CoV and MERS-CoV, milnopiravir improved lung function, reduced viral loads, and improved infection-related weight loss. Other preliminary studies showed that molnopiravir also kills SARS-CoV-2-infected cells in the human respiratory tract. New clinical data shows that molnopiravir can eliminate the worst-case scenario for COVID if used early. 19. Its easy-to-mouth pill is also an advantage to consider. Remdesivir, another antiviral medicine used against COVID-19, must be given intravenously. If Mulnopiravir is approved, it will certainly be another useful tool against COVID-19. Nevertheless, vaccines will remain the best way to eliminate the epidemic and will not only eliminate serious diseases and hospitalizations, but also infection and its transmission.
Meet Molnopiravir, the Thor-inspired Merck Pill Invading COVID
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