The experiment was too small to conclusively compare the vehicles, but Modena may have an advantage. The booster dose is based on preliminary data released Wednesday from a clinical trial conducted by the National Institutes of Health.
This trial confirms what some have long hoped: the combination and adaptation of vaccines could provide stronger and broader protection against the pandemic virus and all its variants.
This test was not large enough to determine which vaccine combination would provide the best protection. And the preliminary results, which are available on the prepress server, have not yet been reviewed. But preliminary experimental results suggest that the Moderna mRNA vaccine may offer the strongest protection worldwide — backed by similar findings from previous vaccine efficacy studies. The data also suggests that people who have received the Johnson & Johnson vaccine may want to get boosted with one of two mRNA vaccines, Moderna or Pfizer/BioNTech. But apparently, this study found that boosting synthesis and play increases protection and only causes side effects similar to boosting a vaccine. Or in the words of the authors: “These data indicate that if a vaccine is approved or licensed, an immune response is produced regardless of the initial Covid-19 vaccination regimen.” For the study, researchers recruited 458 people over the age of 18 at various testing centers across the country. The subjects were then divided into three groups of about 150 each. These three groups had different primary vaccination regimens: either two doses of Moderna vaccine, two doses of Pfizer/BioNTech vaccine, or one injection of Johnson & Johnson vaccine.Advertising
From there, each of the three groups of 150 people was divided into three groups of 50 people, and each of the smaller groups received different speakers. For example, of 151 people who received the Moderna vaccine for the first time, 51 people received a Moderna booster, 51 people received a Pfizer/BioNTech booster, and 49 people received a Johnson & Johnson booster. Booster doses were given between 12 and 29 weeks after the initial vaccination.
Next, the researchers looked at levels of binding and neutralizing antibodies on the day of the booster injection (so before the boosters hit), and examined 29 days later. In all of these compounds, the level of binding antibodies increased between fourfold and 56fold. In people who received the same type of vaccine for their initial and booster doses, the level of neutralizing antibody increased from four to twenty times. In people who received different vaccines, the level of neutralizing antibodies increased six-fold to 76-fold. But folding changes can mask some of the nuances. (You can see an overview of the results here, starting on page 27) The break-even rate has started. Antibody levels on the first day. The geometric mean of neutralizing antibodies ranged from 7.6 to 9 on day 1. In this way, they had the smallest and largest changes after the increase. Johnson & Johnson group members, who used Johnson & Johnson Booster, quadrupled their antibody levels after just 15 days (up to 31 days) — the smallest change of all groups. But the number of people who received the Johnson & Johnson vaccine, followed by the Moderna Booster vaccine, increased 76-fold (to 676) — the biggest change. Moderna booster recipients had the highest level of neutralizing antibodies, regardless of which vaccine they initially received. The geometric mean of neutralizing antibodies ranged from 676 to 900 at day 15. The group received, at an average of 900 - the highest level reported in the study - the Moderna vaccine for initial and booster doses. Subjects who initially received the Pfizer/BioNTech vaccine, after the Moderna booster, increased their geometric mean neutralizing antibodies from 25 to 786. It was observed in subjects initially vaccinated with the Pfizer/BioNTech vaccine. Its range was 58-89 and 19-25, respectively. The subjects were initially vaccinated and their levels increased from 21 to 448 with the Pfizer/BioNTech vaccine. But that's still lower than the people initially vaccinated with Moderna and vaccinated with Pfizer/BioNtech -- their number rose from 58 to 678 after 25 days. The authors note that previous studies had estimated that a geometric mean neutralizing antibody titer of 100 or higher was associated with a 90.7% rate of vaccine efficacy against symptomatic disease. All groups had this threshold, except for the group that received the Johnson & Johnson dose of the initial dose and the booster dose. Enhanced protection Researchers need to conduct more extensive studies to see if Moderna can maintain its leadership here. But Johnson & Johnson's poor results when FDA advisors discuss later this week to review licenses for a booster dose of Johnson & Johnson provide plenty of room for discussion.
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