Both draft manuscripts consider the long-term protection afforded by the vaccine. It has also been linked to some rare side effects of blood clotting, which recently led the CDC to reconsider its approval of the vaccine. However, vaccines are easy to produce, transport and maintain, and there are indications that they have longer protection than some alternatives. There are also indications that at least some of the differences in effectiveness are due to its use as a single-dose vaccine. p>
Because all vaccines are expected to have a large booster after the initial vaccine dose, we are beginning to understand how the J&J vaccine works in more than one dose. Preliminary results showed that the mRNA dose J&J vaccine caused a significant increase in protective antibodies. But the J&J/J&J combination doesn't seem to be very effective. p>
Recent research advances may indicate that protection increases over time, including that of antibody-producing and providing immune cells. Some omicron type protection.
Change over time
One manuscript traces a very large clinical trial involving the administration of a second dose of J&J vaccine to African health care workers. South was six. Nine months after the first dose. The timing of the trial meant that many participants were boosted shortly before oomicron infections increased in that country.
The team tracked test results in participants and collected data on complex factors such as age group. Known risk factors On the basis of the need for hospitalization, the booster was clearly effective and its efficacy increased over time. In the two weeks following reinforcement, the effectiveness in preventing hospitalization was 63%. However, after two weeks, the rate rose to 84% and remained after at least two months. p> Advertising
This increase in effectiveness occurred even when omicron was replacing Delta as the main source of new infections. In South Africa. Therefore, this appears to be consistent with other findings showing that boosters contribute to a significantly higher degree of protection than initial vaccination doses alone. p>
This protection is despite the fact that the level of antibodies produced by J&J is lower in serum. Compared to those who received the mRNA vaccine. As a result, South African researchers suggested that their findings “indicate that protection against severe disease may be due to cellular immunity and immune memory rather than neutralizing antibodies.” Which takes us to the second edition, which deals with cellular immunity produced by immune T cells.
This is a much smaller study with only 20 participants. From the Boston area but the safety response is seen in more detail. It also examines people who received one or two doses, but because of the small population studied, there are not enough people in either group to perform a separate analysis of these populations. p>
In any case, antibodies are a symptom. A moderate but long-term response peaking approximately 2 months after vaccination. Their level at day 240 was still almost double that observed 1 month after vaccination. Neutrality against the delta variant was also relatively strong and decreased by less than a third compared to the response to the initial strains. p>
But when researchers identified the T cells that identified and helped kill infected people, they looked at impressive results. cells. There was no fundamental difference in these individuals in any time period studied. Other types of T cells decreased somewhat, but remained strong for up to eight months. Again, these are Preliminary results from a small study, but they appear consistent with other reports of the long-term safety produced by the Johnson & Johnson vaccine. p>
We are still far from fully understanding the drug's interaction. we've got. Vaccine-based immunity and the different types currently in circulation, as well as differences that may arise from different methods of immunogenicity. But many people, both in the United States and abroad, have now received the Johnson & Johnson vaccine, and understanding whether they are at greater risk over time is critical to managing future epidemics. p>
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