https://safirsoft.com Omicron broke US records because experts are still trying to understand it

The kindness of Omicron and the use of rapid tests remains in question. The average daily number of Covid-19 cases in the United States reached more than 267,000 on Tuesday, a record number largely due to a transmissible virus that experts are still struggling to understand.

The current seven-day average is 267,305 per day, which is higher than the previous record of around 250,000 set in early January 2021. The current vertical increase in cases is expected to continue in the coming weeks. "The rapid increase in the number of cases we're seeing across the country is very much a reflection of the non-transmissible type of omicron," said Dr. Rochelle Valinsky, director of the Centers for Disease Control and Prevention. White House press conference on Wednesday.

Omicron was first seen in the United States just four weeks ago, on December 1. And although in the midst of a furious wave of highly transportable deltas, Omicron quickly ousted the delta and became himself. Prevalent species in the United States According to the latest genetic data, the CDC estimates that Omicron accounted for about 59 percent of all cases nationwide in the week ending December 25. Cases are now up 60 percent from the previous week.

In a few weeks, Omicron has grown rapidly across the country, and we expect it to continue trading in the coming weeks. About this type, especially with regard to the extent of vaccine resistance and current trials to it, and the severity of Omicron infection.

Disease

Vaccines and data to date show that Omicron is present, and that it can inhibit immune defense elicited by previous vaccines and infections, but booster doses appear to restore protection to delta-era levels.

Regarding disease severity, all data still shows that omicrons are less severe than previous types, but it is not yet clear whether this is because omicrons are inherently virulent or that many people have less disease because they are already immune to Vaccination and/or previous infection - or a combination of myco-viral characteristics and previous immunity.

Several laboratory studies in rodent models have shown that Omicron may be present in rapid dissemination into the upper respiratory tract, but less effective in infecting lower parts of the lungs where severe disease may be present. Omicron current wave. The hospital death rate decreased from 21.3% to 4.5%. Admissions to intensive care units fell from 4.3 percent to 1 percent. Patients requiring supplemental oxygen were reduced from 99% to 45%. The average length of hospital stay decreased from 8.8 days to four days.

But the patients were younger in the Omicron wave - with a mean age of 39 compared to a median age of 49 in previous waves. Young people are more likely to develop mild disease.

At a press conference, Anthony Fauci, chief infectious disease specialist, emphasized that researchers in South Africa had milder manifestations of “high levels of past infection and, to a lesser extent, “vaccination coverage of the population.” Fauci went on to point out Similar trends appear to be developing in Britain and even here in the US “They are out of proportion to the increase in hospitalization.” p> This may partly be due to the fact that hospitalizations and deaths always increase with delay. The increase in Omicron is relatively new.” However, the pattern and the difference between cases and hospitalizations strongly suggests that there will be a lower rate of hospitalization to make the situation clearer.

Rapid Confusion

Another aspect of the Omicron case that remains unclear is the role of the rapid test. On Tuesday, the US Food and Drug Administration issued a vague statement saying that the current rapid tests on the market could It could detect an omicron, but "may have reduced sensitivity." It's not clear what it means in practice. The FDA also said the rapid tests may only be less sensitive when trying to detect live viruses. When the researchers used the inactivated virus, they were Rapid tests are as effective in detecting omicrons as they have been in identifying deltas and other species.The agency has not released further details or data from the tests performed and the individual tests that were rapidly evaluated.

Rapid tests often identify the nucleocapsid protein of SARS viruses -CoV-2, not the spike protein, which they are.Omicron-related mutations are found.Nuclear capsid proteins are generally less likely to mutate, and the Omicron carries only a few protein mutations.

Evaluated. Market for its ability to detect n AR Omicron. The agency used a lab-grown Omicron virus from clinical samples. They did not find any decrease in the performance of the rapid test against Omicron.

"In summary, the [rapid experiments] evaluated, all targeting the nucleocapsid protein, identified a new type of Omicron with four modifications." The main sequence is viral,” concludes the technical report. “This does not affect their performance in the lab, and we will monitor subsequent changes as they occur as part of our ongoing evaluation program.”

Test Questions

"What the FDA said: When they looked at allergies. According to Omicron, in some experiments there appears to be some decrease in sensitivity - not disappearance, but decrease. “The fact that the sensitivity has decreased somewhat does not negate the importance...and the usefulness of these tests in different situations. That was the message of the FDA. They wanted to make sure of that by saying that the sensitivity might be a little reduced.” It's completely transparent. But they emphasized that there is still significant use for these trials.” It does not recommend periods of isolation. This week the CDC shortened the recommended isolation period for asymptomatic individuals who test positive for COVID-19, from 10 days to 5 days, reduce masking for another five days. But the new guidelines do not include advice for people waiting for a negative test result to end isolation sooner, which some experts have described as “reckless.” Tests five days after infection may not be a “good indicator of infection.” In other words, rapid tests may be so sensitive that they remain positive after the other person has not been infected.

On the other hand, we know that after five days, people are less likely to transmit the virus... Valensky added that coverage It reduces these risks. That is why people have to wear masks for five days after five days of isolation.” To use it. People exposed or at risk of contracting Covid-19 must undergo several rapid tests over several days.



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