This device kills the brain when it detects neural activity associated with irrational thoughts. emotions.
At a press conference prior to the study's publication, the 36-year-old patient, who asked only for Sarah's name, said the implant was disfigured. His life five years later was a major depression that did not respond to any combination of medications or seizures. “I was tortured with suicidal thoughts every day,” he said. "I was at the end of the line."
The device helped almost immediately after being inserted deep into his brain, which has been going on for a year now. When it detects neural activity associated with irrational thoughts, which previously led to obsessive-compulsive disorder, its electrodes deliver a short, disgusting electrical pulse, which, according to Sarah, "stops the cycle." Deep brain stimulation (DBS) has recently become a popular treatment for epilepsy and Parkinson's disease, but has had limited success with depression, affecting 280 million people worldwide, according to the World Health Organization. About 30% of patients with depression do not respond well to current treatments.Advertising
The problem with electronics use in depression is that scientists have relatively little information about the brain circuits associated with the disease. The UCSF team's main discovery was a "biomarker" that showed signs of depression, a specific pattern of neural activity in a part of the brain called the amygdala that responds to threats. The DBS device used in this study was adapted from the study used to treat epilepsy. When it detects a vital sign in the amygdala, it sends small electrical impulses to another area, the ventral striatum, which is part of the brain's reward and pleasure system. Instantly relieves unwanted mood symptoms. Samir Seth, a neurosurgeon at Baylor College of Medicine in Houston who was not involved in the UCSF research, is conducting another trial of a personal transplant to treat depression. To publish the positive results, he said, the two projects represent a research process to develop a "more personalized approach to psychotherapy" based on stimulating specific circuits in the brain. Although the procedure was promising, Sarah was the first patient in the first case. Skanjus enrolled two other people with major depression to participate in the study, which targeted a total of 12 patients.
"We need to look at how these circuits change in patients and repeat this multiple times." "And we have to see if the biomarkers or the circuit of the brain change over time as treatment continues," he said. And the potentially dangerous approach when Skingos better understand the details of brain circuits after depression, "we hope to find non-invasive biomarkers that can be used in non-invasive therapies."
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Brain implants relieve severe depression in 'prominent' US study
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